Rotundine ntụ ntụ dị ọcha (l-tetrahydropalmatine, l-THP)

Rotundine, nke a makwaara dị ka l-tetrahydropalmatine (l-THP), bụ onyinye nwere ọgwụ ọgwụ na-emetụta usoro nhụjuanya nke etiti na usoro obi. A kọwo na ọ nwere analgesic, ogwuura, hypnotic, na anxiolytic mmetụta. Na mgbakwunye, egosila na ọ nwere mmetụta nchebe na mmerụ ahụ nke ischemia myocardial na myocardial. A makwaara Rotundine maka ikike ọ nwere igbanwe nguzogide ọtụtụ ọgwụ na mkpụrụ ndụ kansa yana ihe mgbochi ọwa calcium ya.
Enwere ike nweta ya site na tubers nke Stephania tetrandra na Corydalis yanhusuo, ma ọ bụ site na usoro njikọ kemịkal. Ejikọtara site na tetrahydropalmatine site na mbelata, mkpochapụ na mmeghachi omume alkalization. Enwere ike imepụta tetrahydropalmatine ajị anụ site na tetrahydropalmatine site na alkalization na oxidation maka njikọ a na-emegharị ugboro ugboro.
Maka pharmacokinetics, Rotundine na-etinye uche nke ọma mgbe nchịkwa ọnụ gasịrị ma na-ekesa ya na anụ ahụ adipose, na-esote ngụgụ, imeju, na akụrụ. A na-esikarị na akụrụ pụtapụta ya. Nnyocha e mere na òké na oke bekee egosila na Rotundine nwere ike ịbanye n'ime ihe mgbochi ụbụrụ ọbara wee banye n'anụ ahụ, na ụbụrụ ụbụrụ dị ala karịa ọbara ọbara mgbe awa 2 gachara.
Maka mmetụta ọjọọ, Rotundine nwere ike ịkpata iro ụra, isi ọwụwa, ike ọgwụgwụ, ọgbụgbọ, na ihe nfụkasị ahụ mgbe ụfọdụ. Akpachara anya na-agụnye izere iji ụmụ nwanyị dị ime na ndị na-enye nwa ara, ịmara ikike nke ndidi na iji ogologo oge eme ihe, na iji nlezianya mee ihe mgbe a na-ejikọta ya na usoro nhụjuanya nke etiti ahụ, na nhazi usoro onunu ogwu kwesịrị ekwesị ma ọ bụrụ na ọ dị mkpa.
Na nchịkọta, Rotundine bụ ngwakọta nke nwere mmetụta ọgwụ dịgasị iche iche, na ihe onwunwe ya na-eme ka ọ bụrụ isiokwu nke mmasị na nchọpụta dị iche iche, gụnyere nlekọta mgbu, ahụike obi obi, na ọgwụgwọ ọrịa cancer. Maka ozi ndị ọzọ kpọtụrụgrace@biowaycn.com.