I. Okwu Mmalite
Phospholipids bụ akụkụ dị mkpa nke akpụkpọ ahụ sel ma na-arụ ọrụ dị oke mkpa n'ịnọgide na-enwe iguzosi ike n'ezi ihe na ọrụ nke mkpụrụ ndụ ụbụrụ. Ha na-emepụta lipid bilayer nke gbara ma na-echebe neurons na mkpụrụ ndụ ndị ọzọ dị n'ụbụrụ, na-enye aka na ọrụ zuru oke nke sistemụ akwara etiti. Na mgbakwunye, phospholipids na-etinye aka na ụzọ mgbaàmà dị iche iche na usoro neurotransmission dị mkpa maka ọrụ ụbụrụ.
Ahụike ụbụrụ na ọrụ nghọta dị mkpa maka ọdịmma na ịdị mma nke ndụ. Usoro uche dịka icheta ihe, nlebara anya, idozi nsogbu, na ime mkpebi dị mkpa maka ọrụ kwa ụbọchị ma dabere na ahụike na ọrụ kwesịrị ekwesị nke ụbụrụ. Ka ndị mmadụ na-aka nká, ichekwa ọrụ nghọta na-aghọwanye ihe dị mkpa, na-eme ka ọmụmụ ihe nke ihe ndị na-emetụta ahụike ụbụrụ dị oke mkpa maka ịgwọ ọdịda uche nke afọ na nsogbu nghọta dịka isi mgbaka.
Ebumnuche nke ọmụmụ ihe a bụ inyocha ma nyochaa mmetụta nke phospholipids nwere n'ahụike ụbụrụ na ọrụ nghọta. Site n'inyocha ọrụ nke phospholipids na-arụ n'ịkwado ahụike ụbụrụ na ịkwado usoro nghọta, ọmụmụ ihe a na-achọ inye nghọta miri emi nke mmekọrịta dị n'etiti phospholipids na ọrụ ụbụrụ. Na mgbakwunye, ọmụmụ ihe a ga-enyocha mmetụta nwere ike inwe na ọgwụgwọ ebumnuche iji chekwaa ma melite ahụike ụbụrụ na ọrụ nghọta.
II. Ịghọta Phospholipids
A. Nkọwa nke phospholipids:
Phospholipidsbụ otu ụdị lipids nke bụ isi ihe dị mkpa n'ime akpụkpọ ahụ niile, gụnyere ndị dị n'ụbụrụ. Ha mejupụtara molekul glycerol, asịd abụba abụọ, otu phosphate, na otu isi polar. A na-amata phospholipids site na ọdịdị amphiphilic ha, nke pụtara na ha nwere ma hydrophilic (na-adọta mmiri) na mpaghara hydrophobic (na-egbochi mmiri). Njirimara a na-enye phospholipids ohere ịmepụta bilayer lipid nke na-eje ozi dị ka ntọala nhazi nke membranes cell, na-enye ihe mgbochi n'etiti ime sel na gburugburu ya dị n'èzí.
B. Ụdị phospholipids dị n'ụbụrụ:
Ụbụrụ nwere ọtụtụ ụdị phospholipids, nke kachasị dị na yaphosphatidylcholine, phosphatidylethanolamine,phosphatidylserine, na sphingomyelin. Phospholipids ndị a na-enye aka na njirimara na ọrụ pụrụ iche nke membranes sel ụbụrụ. Dịka ọmụmaatụ, phosphatidylcholine bụ akụkụ dị mkpa nke membranes sel akwara, ebe phosphatidylserine na-etinye aka na transduction mgbaàmà na ntọhapụ neurotransmitter. Sphingomyelin, phospholipid ọzọ dị mkpa nke a na-ahụ na anụ ahụ ụbụrụ, na-arụ ọrụ n'ịnọgide na-eguzosi ike n'ezi ihe nke sheaths myelin nke na-ekpuchi ma na-echebe eriri akwara.
C. Nhazi na ọrụ nke phospholipids:
Nhazi nke phospholipids nwere otu isi phosphate hydrophilic nke ejikọtara na molekul glycerol na ọdụdụ hydrophobic fatty acid abụọ. Nhazi amphiphilic a na-enye ohere ka phospholipids mepụta bilayer lipid, yana isi hydrophilic na-eche ihu n'èzí na ọdụ hydrophobic na-eche ihu n'ime. Nhazi a nke phospholipids na-enye ntọala maka ụdị mosaic mmiri mmiri nke membranes cell, na-eme ka ikike nhọrọ dị mkpa maka ọrụ cell. N'ọrụ, phospholipids na-arụ ọrụ dị oke mkpa n'ịnọgide na-eguzosi ike n'ezi ihe na ọrụ nke membranes cell. Ha na-enye aka na nkwụsi ike na mmiri nke membranes cell, na-eme ka njem nke molekul dị mfe gafee membrane, ma na-esonye na mgbama sel na nkwukọrịta. Na mgbakwunye, ụdị phospholipids ụfọdụ, dị ka phosphatidylserine, ejikọtala na ọrụ nghọta na usoro ebe nchekwa, na-egosipụta mkpa ha dị na ahụike ụbụrụ na ọrụ nghọta.
III. Mmetụta nke Phospholipids na Ahụike Ụbụrụ
A. Nlekọta nke nhazi mkpụrụ ndụ ụbụrụ:
Phospholipids na-arụ ọrụ dị mkpa n'ịnọgide na-enwe nguzozi nhazi nke mkpụrụ ndụ ụbụrụ. Dịka akụkụ dị mkpa nke membranes sel, phospholipids na-enye usoro bụ isi maka nhazi na ọrụ nke neurons na mkpụrụ ndụ ụbụrụ ndị ọzọ. Phospholipid bilayer na-emepụta ihe mgbochi na-agbanwe agbanwe ma na-agbanwe agbanwe nke na-ekewapụ gburugburu ime nke mkpụrụ ndụ ụbụrụ site na gburugburu mpụga, na-achịkwa ntinye na ọpụpụ nke mkpụrụ ndụ na ion. Nguzozi nhazi a dị oke mkpa maka ọrụ kwesịrị ekwesị nke mkpụrụ ndụ ụbụrụ, ebe ọ na-eme ka mmezi nke homeostasis intracellular, nkwukọrịta n'etiti mkpụrụ ndụ, na nnyefe nke akara akwara.
B. Ọrụ na mgbasa ozi akwara ozi:
Phospholipids na-enye aka nke ukwuu na usoro nke nnyefe akwara ozi, nke dị mkpa maka ọrụ nghọta dị iche iche dịka mmụta, ncheta, na nhazi ọnọdụ uche. Nkwukọrịta akwara na-adabere na ntọhapụ, mgbasa, na nnabata nke neurotransmitters n'ofe synapses, phospholipids na-etinyekwa aka kpọmkwem na usoro ndị a. Dịka ọmụmaatụ, phospholipids na-eje ozi dị ka ihe ndị na-ebute ụzọ maka njikọta nke neurotransmitters ma na-agbanwe ọrụ nke ndị na-anabata neurotransmitters na ndị na-ebuga ya. Phospholipids na-emetụtakwa mmiri mmiri na permeability nke membranes cell, na-emetụta exocytosis na endocytosis nke vesicles nwere neurotransmitters na nhazi nke nnyefe synaptic.
C. Nchedo megide nrụgide oxidative:
Ụbụrụ na-enwe nsogbu karịsịa maka mmebi oxidative n'ihi oke oxygen ya, oke polyunsaturated fatty acids, na obere usoro nchekwa antioxidant. Phospholipids, dịka ihe ndị bụ isi mejupụtara membranes cell, na-enye aka na nchekwa megide nrụgide oxidative site n'ịrụ ọrụ dị ka ihe mgbaru ọsọ na ebe nchekwa maka molekul antioxidant. Phospholipids nwere ogige antioxidant, dị ka vitamin E, na-arụ ọrụ dị mkpa n'ichebe mkpụrụ ndụ ụbụrụ site na lipid peroxidation na ịnọgide na-enwe iguzosi ike n'ezi ihe na mmiri mmiri. Ọzọkwa, phospholipids na-ejekwa ozi dị ka mkpụrụ ndụ ihe mgbaàmà na ụzọ nzaghachi cell nke na-egbochi nrụgide oxidative ma na-akwalite ndụ sel.
IV. Mmetụta nke Phospholipids na Ọrụ Ọgụgụ Isi
A. Nkọwa nke phospholipids:
Phospholipids bụ otu ụdị lipids nke bụ isi ihe dị na akpụkpọ ahụ niile, gụnyere ndị dị n'ụbụrụ. Ha mejupụtara glycerol molecule, fatty acids abụọ, otu phosphate, na otu isi polar. A na-amata Phospholipids site na ọdịdị amphiphilic ha, nke pụtara na ha nwere ma hydrophilic (na-adọta mmiri) na mpaghara hydrophobic (na-egbochi mmiri). Njirimara a na-enye phospholipids ohere ịmepụta bilayer lipid nke na-eje ozi dị ka ntọala nhazi nke membranes cell, na-enye ihe mgbochi n'etiti ime sel na gburugburu ya dị n'èzí.
B. Ụdị phospholipids dị n'ụbụrụ:
Ụbụrụ nwere ọtụtụ ụdị phospholipids, nke kachasị ukwuu bụ phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, na sphingomyelin. Phospholipids ndị a na-enye aka na njirimara na ọrụ pụrụ iche nke membranes cell ụbụrụ. Dịka ọmụmaatụ, phosphatidylcholine bụ ihe dị mkpa nke membranes cell akwara, ebe phosphatidylserine na-etinye aka na transduction mgbaàmà na ntọhapụ neurotransmitter. Sphingomyelin, phospholipid ọzọ dị mkpa a na-ahụ na anụ ahụ ụbụrụ, na-arụ ọrụ n'ịnọgide na-eguzosi ike n'ezi ihe nke sheaths myelin nke na-ekpuchi ma na-echebe eriri akwara.
C. Nhazi na ọrụ nke phospholipids:
Nhazi nke phospholipids nwere otu isi phosphate hydrophilic nke ejikọtara na molekul glycerol na ọdụdụ hydrophobic fatty acid abụọ. Nhazi amphiphilic a na-enye ohere ka phospholipids mepụta bilayer lipid, yana isi hydrophilic na-eche ihu n'èzí na ọdụ hydrophobic na-eche ihu n'ime. Nhazi a nke phospholipids na-enye ntọala maka ụdị mosaic mmiri mmiri nke membranes cell, na-eme ka ikike nhọrọ dị mkpa maka ọrụ cell. N'ọrụ, phospholipids na-arụ ọrụ dị oke mkpa n'ịnọgide na-eguzosi ike n'ezi ihe na ọrụ nke membranes cell. Ha na-enye aka na nkwụsi ike na mmiri nke membranes cell, na-eme ka njem nke molekul dị mfe gafee membrane, ma na-esonye na mgbama sel na nkwukọrịta. Na mgbakwunye, ụdị phospholipids ụfọdụ, dị ka phosphatidylserine, ejikọtala na ọrụ nghọta na usoro ebe nchekwa, na-egosipụta mkpa ha dị na ahụike ụbụrụ na ọrụ nghọta.
V. Ihe Ndị Na-emetụta Ọkwa Phospholipid
A. Isi mmalite nri nke phospholipids
Phospholipids bụ ihe dị mkpa maka nri dị mma, enwere ike inweta ha site na ọtụtụ ebe nri dị iche iche. Isi mmalite nri phospholipids gụnyere àkwá yolks, soybeans, anụ akụkụ ahụ, na ụfọdụ nri mmiri dị ka herring, mackerel, na salmon. Akpa àkwá, karịsịa, bara ụba na phosphatidylcholine, otu n'ime phospholipids kachasị ukwuu n'ụbụrụ na ihe na-ebute neurotransmitter acetylcholine, nke dị oke mkpa maka ncheta na ọrụ ọgụgụ isi. Na mgbakwunye, soybeans bụ isi iyi dị mkpa nke phosphatidylserine, phospholipid ọzọ dị mkpa nwere mmetụta bara uru na ọrụ ọgụgụ isi. Iji hụ na oriri kwesịrị ekwesị nke isi mmalite nri ndị a nwere ike inye aka na ịnọgide na-enwe ọkwa phospholipid kacha mma maka ahụike ụbụrụ na ọrụ ọgụgụ isi.
B. Ụdị Ndụ na Ihe Ndị Gbasara Gburugburu Ebe Obibi
Ụdị ndụ na ihe ndị metụtara gburugburu ebe obibi nwere ike imetụta ọkwa phospholipid n'ahụ nke ukwuu. Dịka ọmụmaatụ, nrụgide na-adịghị ala ala na ikpughe na nsị gburugburu ebe obibi nwere ike ibute mmụba nke mmepụta nke molekul mkpali nke na-emetụta nhazi na iguzosi ike n'ezi ihe nke akpụkpọ ahụ sel, gụnyere ndị dị n'ụbụrụ. Ọzọkwa, ihe ndị dị ndụ dịka ise siga, ịṅụbiga mmanya ókè, na nri nwere abụba trans na abụba juru eju nwere ike imetụta metabolism na ọrụ phospholipid n'ụzọ na-adịghị mma. N'aka nke ọzọ, mmega ahụ mgbe niile na nri bara ụba na antioxidants, omega-3 fatty acids, na ihe ndị ọzọ dị mkpa nwere ike ịkwalite ọkwa phospholipid dị mma ma kwado ahụike ụbụrụ na ọrụ ọgụgụ isi.
C. Ike maka mgbakwunye
Ebe ọ bụ na phospholipids dị mkpa n'ahụike ụbụrụ na ọrụ nghọta, enwere mmasị na-eto eto n'ike maka mgbakwunye phospholipid iji kwado ma melite ọkwa phospholipid. A mụọla ihe mgbakwunye phospholipid, karịsịa ndị nwere phosphatidylserine na phosphatidylcholine sitere na isi mmalite dị ka soy lecithin na phospholipids mmiri, maka mmetụta ha na-eme ka nghọta dịkwuo mma. Nnwale ahụike egosila na mgbakwunye phospholipid nwere ike imeziwanye ebe nchekwa, nlebara anya, na ọsọ nhazi na ma ndị okenye na ndị okenye. Ọzọkwa, mgbakwunye phospholipid, mgbe ejikọtara ya na omega-3 fatty acids, egosila mmetụta synergistic n'ịkwalite ịka nká ụbụrụ na ọrụ nghọta.
VI. Ọmụmụ na Nchọpụta Nnyocha
A. Nchịkọta nke Nnyocha Dị Mkpa na Phospholipids na Ahụike Ụbụrụ
Phospholipids, bụ́ isi ihe mejupụtara akpụkpọ ahụ mkpụrụ ndụ, na-arụ ọrụ dị mkpa n'ahụike ụbụrụ na ọrụ nghọta. Nnyocha banyere mmetụta nke phospholipids na ahụike ụbụrụ elekwasịla anya n'ọrụ ha na synaptic plasticity, ọrụ neurotransmitter, na arụmọrụ nghọta zuru oke. Ọmụmụ ihe enyochaala mmetụta nke phospholipids nri, dị ka phosphatidylcholine na phosphatidylserine, na ọrụ nghọta na ahụike ụbụrụ na ma anụmanụ ma ndị mmadụ. Na mgbakwunye, nnyocha enyochaala uru ndị nwere ike ịnweta site na mgbakwunye phospholipid n'ịkwalite mmụba nghọta na ịkwado ịka nká ụbụrụ. Ọzọkwa, ọmụmụ ihe onyonyo neuro enyela nghọta banyere mmekọrịta dị n'etiti phospholipids, nhazi ụbụrụ, na njikọ ọrụ, na-eme ka a mata usoro ndị na-akpata mmetụta nke phospholipids na ahụike ụbụrụ.
B. Ihe Ndị Dị Mkpa Achọpụtara na Mmechi Site na Ọmụmụ Ihe
Mmezi nke nghọta:Ọtụtụ nnyocha egosila na phospholipids nri, karịsịa phosphatidylserine na phosphatidylcholine, nwere ike ime ka akụkụ dị iche iche nke ọrụ nghọta dịkwuo mma, gụnyere ebe nchekwa, nlebara anya, na ọsọ nhazi. N'ime nnwale ahụike nke a na-achịkwa n'usoro, nke a na-achịkwa site na placebo, achọpụtara na mgbakwunye phosphatidylserine na-eme ka ebe nchekwa dịkwuo mma na mgbaàmà nke nsogbu enweghị nlebara anya na-adịghị mma na ụmụaka, na-atụ aro ojiji ọgwụgwọ nwere ike maka mmụba nghọta. N'otu aka ahụ, mgbakwunye phospholipid, mgbe ejikọtara ya na omega-3 fatty acids, egosila mmetụta synergistic n'ịkwalite arụmọrụ nghọta na ndị nwere ahụike n'ofe afọ dị iche iche. Nchọpụta ndị a na-egosi ike nke phospholipids dị ka ihe na-eme ka nghọta dịkwuo mma.
Nhazi na Ọrụ Ụbụrụ: Ọmụmụ ihe gbasara akwara ozi enyela ihe akaebe nke njikọ dị n'etiti phospholipids na nhazi ụbụrụ yana njikọ ọrụ. Dịka ọmụmaatụ, ọmụmụ ihe gbasara magnetic resonance spectroscopy ekpughewo na ọkwa phospholipid na mpaghara ụbụrụ ụfọdụ nwere njikọ na arụmọrụ nghọta na mbelata ọgụgụ isi metụtara afọ. Na mgbakwunye, ọmụmụ ihe gbasara mgbasa tensor onyonyo egosila mmetụta nke nhazi phospholipid na iguzosi ike n'ezi ihe nke ihe ọcha, nke dị oke mkpa maka nkwukọrịta akwara ozi nke ọma. Nchọpụta ndị a na-egosi na phospholipids na-arụ ọrụ dị mkpa n'ịnọgide na-enwe nhazi na ọrụ ụbụrụ, si otú a na-emetụta ikike nghọta.
Mmetụta Maka Ịka nká Ụbụrụ:Nnyocha e mere na phospholipids nwekwara mmetụta dị na ịka nká ụbụrụ na ọnọdụ neurodegenerative. Ọmụmụ ihe egosila na mgbanwe na nhazi phospholipid na metabolism nwere ike itinye aka na mbelata ọgụgụ isi metụtara afọ na ọrịa neurodegenerative dị ka ọrịa Alzheimer. Ọzọkwa, mgbakwunye phospholipid, karịsịa na ilekwasị anya na phosphatidylserine, egosila nkwa n'ịkwado ịka nká ụbụrụ dị mma ma nwee ike ibelata mbelata ọgụgụ isi metụtara ịka nká. Nchọpụta ndị a na-egosi mkpa phospholipids dị na ọnọdụ ịka nká ụbụrụ na nkwarụ ọgụgụ isi metụtara afọ.
VII. Mmetụta Ahụike na Ntuziaka Maka Ọdịnihu
A. Ngwa ndị nwere ike ime maka ahụike ụbụrụ na ọrụ nghọta
Mmetụta nke phospholipids nwere n'ahụike ụbụrụ na ọrụ nghọta nwere mmetụta dị ukwuu maka ojiji nwere ike ime na ebe ahụike. Ịghọta ọrụ nke phospholipids n'ịkwado ahụike ụbụrụ na-emepe ụzọ maka ọgwụgwọ ọhụrụ na atụmatụ mgbochi ebumnuche iji melite ọrụ nghọta na ibelata mbelata nghọta. Ngwa ndị nwere ike itinye gụnyere mmepe nke nri dabere na phospholipid, usoro mgbakwunye ahaziri ahazi, na ụzọ ọgwụgwọ ezubere maka ndị mmadụ nọ n'ihe ize ndụ nke nkwarụ nghọta. Na mgbakwunye, ojiji nke phospholipid dabere na ya nwere ike iji kwado ahụike ụbụrụ na ọrụ nghọta na ọtụtụ ndị ọrịa, gụnyere ndị agadi, ndị nwere ọrịa neurodegenerative, na ndị nwere ụkọ nghọta, nwere nkwa maka imeziwanye nsonaazụ nghọta zuru oke.
B. Ihe ndị a ga-atụle maka nyocha ọzọ na nnwale ahụike
Nnyocha ndị ọzọ na nnwale ahụike dị oke mkpa iji mee ka nghọta anyị banyere mmetụta nke phospholipids nwere na ahụike ụbụrụ na ọrụ nghọta na ịtụgharị ihe ọmụma dị ugbu a ka ọ bụrụ ọgwụgwọ dị irè. Ọmụmụ ihe ndị ga-eme n'ọdịnihu kwesịrị ịkọwa usoro ndị dị n'okpuru mmetụta nke phospholipids na ahụike ụbụrụ, gụnyere mmekọrịta ha na sistemụ neurotransmitter, ụzọ mgbaama sel, na usoro plasticity neural. Ọzọkwa, achọrọ nnwale ahụike ogologo oge iji nyochaa mmetụta ogologo oge nke phospholipid na ọrụ nghọta, ịka nká ụbụrụ, na ihe egwu nke ọnọdụ neurodegenerative. Ihe ndị a ga-atụle maka nyocha ọzọ gụnyekwara ịchọpụta mmetụta synergistic nke phospholipids nwere ike inwe na ihe ndị ọzọ na-arụ ọrụ bioactive, dị ka omega-3 fatty acids, n'ịkwalite ahụike ụbụrụ na ọrụ nghọta. Na mgbakwunye, nnwale ahụike nke a haziri ahazi nke lekwasịrị anya na ndị ọrịa ụfọdụ, dị ka ndị mmadụ n'otu n'otu na ọkwa dị iche iche nke nsogbu nghọta, nwere ike inye nghọta bara uru na ojiji ahaziri nke phospholipid.
C. Mmetụta dị na ahụike ọha na eze na agụmakwụkwọ
Mmetụta nke phospholipids na ahụike ụbụrụ na ọrụ nghọta na-agbasa na ahụike na agụmakwụkwọ ọha, yana mmetụta nwere ike inwe na atụmatụ mgbochi, amụma ahụike ọha na eze, na atụmatụ agụmakwụkwọ. Mgbasa ozi gbasara ọrụ nke phospholipids na ahụike ụbụrụ na ọrụ nghọta nwere ike inye aka na mkpọsa ahụike ọha na eze nke ebumnuche ya bụ ịkwalite àgwà nri dị mma nke na-akwado oriri phospholipid zuru oke. Ọzọkwa, mmemme agụmakwụkwọ na-elekwasị anya na ọtụtụ mmadụ, gụnyere ndị okenye, ndị na-elekọta, na ndị ọkachamara ahụike, nwere ike ime ka a mara mkpa phospholipids dị n'ịnọgide na-enwe ike nghọta na ibelata ihe egwu nke mbelata nghọta. Ọzọkwa, njikọta nke ozi dabere na ihe akaebe na phospholipids na usoro ọmụmụ agụmakwụkwọ maka ndị ọkachamara ahụike, ndị na-ahụ maka nri, na ndị nkuzi nwere ike ime ka nghọta nke ọrụ nri na ahụike nghọta dịkwuo mma ma nye ndị mmadụ ike ime mkpebi amamihe gbasara ọdịmma nghọta ha.
Nke Asatọ. Mmechi
N'oge nnyocha a nke mmetụta nke phospholipids na ahụike ụbụrụ na ọrụ nghọta, ọtụtụ isi ihe apụtala. Nke mbụ, phospholipids, dị ka ihe dị mkpa nke membranes cell, na-arụ ọrụ dị oke mkpa n'ịnọgide na-enwe iguzosi ike n'ezi ihe na ọrụ nke ụbụrụ. Nke abụọ, phospholipids na-enye aka na ọrụ nghọta site n'ịkwado neurotransmission, synaptic plasticity, na ahụike ụbụrụ dum. Ọzọkwa, phospholipids, karịsịa ndị bara ọgaranya na polyunsaturated fatty acids, ejikọtara ya na mmetụta neuroprotective na uru nwere ike ịba uru maka arụmọrụ nghọta. Na mgbakwunye, ihe oriri na ụdị ndụ nke na-emetụta nhazi phospholipid nwere ike imetụta ahụike ụbụrụ na ọrụ nghọta. N'ikpeazụ, ịghọta mmetụta nke phospholipids na ahụike ụbụrụ dị oke mkpa maka ịmepụta ihe ndị a na-elekwasị anya iji kwalite iguzogide nghọta na ibelata ihe egwu nke mbelata nghọta.
Ịghọta mmetụta nke phospholipids nwere n'ahụike ụbụrụ na ọrụ nghọta dị oke mkpa maka ọtụtụ ihe kpatara ya. Nke mbụ, nghọta dị otú ahụ na-enye nghọta n'ime usoro ọrụ nghọta, na-enye ohere iji mepụta ihe ndị a kapịrị ọnụ iji kwado ahụike ụbụrụ ma melite arụmọrụ nghọta n'oge ndụ niile. Nke abụọ, ka ọnụọgụgụ mmadụ zuru ụwa ọnụ na-akawanye njọ na mmụba nke mbelata nghọta metụtara afọ na-abawanye, ịkọwa ọrụ nke phospholipids na ịka nká nghọta na-aghọwanye ihe dị mkpa maka ịkwalite ịka nká dị mma na ichekwa ọrụ nghọta. Nke atọ, mgbanwe nwere ike ime nke mejupụtara phospholipid site na ntinye aka nri na ụdị ndụ na-emesi mkpa ọ dị mma ịmara na agụmakwụkwọ gbasara isi mmalite na uru nke phospholipids n'ịkwado ọrụ nghọta. Ọzọkwa, ịghọta mmetụta nke phospholipids na ahụike ụbụrụ dị mkpa maka ịgwa atụmatụ ahụike ọha na eze, ntinye aka ahụike, na ụzọ ahaziri iche iji kwalite iguzogide nghọta na ibelata mbelata nghọta.
Na mmechi, mmetụta nke phospholipids na ahụike ụbụrụ na ọrụ nghọta bụ akụkụ dị iche iche na nke na-agbanwe agbanwe nke nyocha nwere mmetụta dị ukwuu maka ahụike ọha, omume ahụike, na ọdịmma onye ọ bụla. Ka nghọta anyị banyere ọrụ nke phospholipids na ọrụ nghọta na-aga n'ihu na-agbanwe, ọ dị mkpa ịghọta ike nke ntinye aka ezubere iche na atụmatụ ahaziri iche nke na-eji uru nke phospholipids eme ihe maka ịkwalite iguzogide nghọta n'oge ndụ niile. Site na itinye ihe ọmụma a na atụmatụ ahụike ọha, omume ahụike, na agụmakwụkwọ, anyị nwere ike inye ndị mmadụ ike ime nhọrọ amamihe dị na ya nke na-akwado ahụike ụbụrụ na ọrụ nghọta. N'ikpeazụ, ịzụlite nghọta zuru oke nke mmetụta nke phospholipids na ahụike ụbụrụ na ọrụ nghọta nwere nkwa maka ịkwalite nsonaazụ nghọta na ịkwalite ịka nká dị mma.
Ntụaka:
1. Alberts, B., et al. (2002). Bayọlọji Mkpụrụ ndụ nke Mkpụrụ ndụ (mbipụta nke anọ). New York, NY: Sayensị Garland.
2. Vance, JE, & Vance, DE (2008). Biosynthesis nke phospholipid na mkpụrụ ndụ anụmanụ. Biochemistry na Cell Biology, 86(2), 129-145. https://doi.org/10.1139/O07-167
3. Svennerholm, L., & Vanier, MT (1973). Nkesa nke lipids n'ime sistemụ akwara mmadụ. II. Nhazi lipid nke ụbụrụ mmadụ n'ihe gbasara afọ, okike, na mpaghara anatomical. Brain, 96(4), 595-628. https://doi.org/10.1093/brain/96.4.595
4. Agnati, LF, & Fuxe, K. (2000). Nnyefe olu dị ka akụkụ dị mkpa nke njikwa ozi na sistemụ akwara etiti. Uru nkọwa ọhụrụ nwere ike ịbụ nke igwe ụdị B nke Turing. Ọganihu na Nnyocha Ụbụrụ, 125, 3-19. https://doi.org/10.1016/S0079-6123(00)25003-X
5. Di Paolo, G., & De Camilli, P. (2006). Phosphoinositides na nhazi mkpụrụ ndụ na usoro akpụkpọ ahụ. Nature, 443(7112), 651-657. https://doi.org/10.1038/nature05185
6. Markesbery, WR, & Lovell, MA (2007). Mmebi nke lipids, protein, DNA, na RNA na obere nsogbu nghọta. Archives of Neurology, 64(7), 954-956. https://doi.org/10.1001/archneur.64.7.954
7. Bazinet, RP, & Layé, S. (2014). Polyunsaturated fatty acids na metabolites ha na ọrụ ụbụrụ na ọrịa. Nature Reviews Neuroscience, 15(12), 771-785. https://doi.org/10.1038/nrn3820
8. Jäger, R., Purpura, M., Geiss, KR, Weiß, M., Baumeister, J., Amatulli, F., & Kreider, RB (2007). Mmetụta nke phosphatidylserine na arụmọrụ golf. Akwụkwọ akụkọ nke International Society of Sports Nutrition, 4 (1), 23. https://doi.org/10.1186/1550-2783-4-23
9. Cansev, M. (2012). Fatty acids dị mkpa na ụbụrụ: Mmetụta ahụike nwere ike inwe. International Journal of Neuroscience, 116(7), 921-945. https://doi.org/10.3109/00207454.2006.356874
10. Kidd, PM (2007). Omega-3 DHA na EPA maka nghọta, omume, na ọnọdụ uche: Nchọpụta ahụike na njikọ nhazi na ọrụ na phospholipids nke membrane cell membrane. Nyocha Ọgwụ Ọzọ, 12(3), 207-227.
11. Lukiw, WJ, & Bazan, NG (2008). Docosahexaenoic acid na ụbụrụ merela agadi. Akwụkwọ akụkọ nke Nutrition, 138(12), 2510-2514. https://doi.org/10.3945/jn.108.100354
12. Hirayama, S., Terasawa, K., Rabeler, R., Hirayama, T., Inoue, T., & Tatsumi, Y. (2006). Mmetụta nke ojiji phosphatidylserine na ncheta na ihe mgbaàmà nke nsogbu hyperactivity-deficit attention-deficit: Nnwale ahụike nke a na-achịkwa site na placebo. Journal of Human Nutrition and Dietetics, 19(2), 111-119. https://doi.org/10.1111/j.1365-277X.2006.00610.x
13. Hirayama, S., Terasawa, K., Rabeler, R., Hirayama, T., Inoue, T., & Tatsumi, Y. (2006). Mmetụta nke ojiji phosphatidylserine na ncheta na ihe mgbaàmà nke nsogbu hyperactivity-deficit attention-deficit: Nnwale ahụike nke a na-achịkwa site na placebo. Journal of Human Nutrition and Dietetics, 19(2), 111-119. https://doi.org/10.1111/j.1365-277X.2006.00610.x
14. Kidd, PM (2007). Omega-3 DHA na EPA maka nghọta, omume, na ọnọdụ uche: Nchọpụta ahụike na njikọ nhazi na ọrụ na phospholipids nke membrane cell membrane. Nyocha Ọgwụ Ọzọ, 12(3), 207-227.
15. Lukiw, WJ, & Bazan, NG (2008). Docosahexaenoic acid na ụbụrụ merela agadi. Journal of Nutrition, 138(12), 2510-2514. https://doi.org/10.3945/jn.108.100354
16. Cederholm, T., Salem, N., Palmblad, J. (2013). ω-3 Fatty acids na mgbochi nke mbelata ọgụgụ isi n'ime ụmụ mmadụ. Ọganihu na Nri, 4(6), 672-676. https://doi.org/10.3945/an.113.004556
17. Fabelo, N., Martín, V., Santpere, G., Marín, R., Torrent, L., Ferrer, I., Díaz, M. (2011). Mgbanwe siri ike na nhazi lipid nke frontal cortex lipid rafts sitere na ọrịa Parkinson na mberede 18. Ọrịa Parkinson. Ọgwụ nke anụ ahụ, 17 (9-10), 1107-1118. https://doi.org/10.2119/molmed.2011.00137
19. Kanoski, SE, na Davidson, TL (2010). Ụdị dị iche iche nke nsogbu ncheta na-esochi mmezi nwa oge na ogologo oge na nri ike dị elu. Journal of Experimental Psychology: Animal Behavior Processes, 36(2), 313-319. https://doi.org/10.1037/a0017318
Oge ozi: Disemba-26-2023
