Corydalis weputara Tetrahydropalmatine (dl-THP)
Tetrahydropalmatine (THP), nke a makwaara dị ka dl-THP, Corydalin hydrochloride, ma ọ bụ Corydalin Tube Extract, bụ ihe nkewa dị ka alkaloid isoquinoline. A na-ewepụta ya na tuber nke ahịhịa ndị China Corydalis yanhusuo. THP bụ ihe na-enweghị agba ma ọ bụ na-acha odo odo na-acha odo odo nke nwere uto dị ilu na ebe agbaze nke 147-149 ° C. Ọ fọrọ nke nta ka ọ bụrụ ihe a na-esighi ike na mmiri mana ọ na-agbaze nke ukwuu na ether, chloroform, na ethanol. Hydrochloride ya na nnu sulfate na-agbaze na mmiri.
A mụọla THP maka mmetụta ọgwụ dị iche iche, gụnyere analgesic, anesthetic, neuroprotective, antiplatelet aggregation, antiulcer, antitumor, na mgbochi riri ahụ. Ekwenyere na ọ ga-egosipụta mmetụta analgesic ya site n'ịgbanwe ọrụ nnabata dopamine etiti ma gosipụta ikike ichebe neurons site na mmerụ ahụ ischemic. Na mgbakwunye, THP egosipụtala mmetụta nchịkọta antiplatelet ma enyocha ya maka ikike ọ nwere n'ịgwọ ọnya, igbochi uto cell tumo, na inye aka na ọgwụ riri ahụ.
N'ozuzu, Tetrahydropalmatine (dl-THP) bụ ngwakọta nwere ụdị ọgwụ dị iche iche ma bụrụkwa isiokwu nke nyocha buru ibu maka ngwa ọgwụgwọ ya nwere ike. Maka ozi ndị ọzọ kpọtụrụgrace@biowaycn.com.
Nke a bụ njirimara ngwaahịa nke Tetrahydropalmatine (THP) yana uru ahụike ha:
1. Njirimara nke analgesic:THP na-egosipụta mmetụta analgesic site n'ịgbanwe ọrụ etiti dopamine receptor, na-enye ihe mgbu na-enweghị ike riri ahụ.
2. Mmetụta Neuroprotective:THP egosila ikike ichebe neurons site na mmerụ ahụ ischemic, ibelata apoptosis neuronal, na ibelata ọkwa glutamate na ụbụrụ, nke nwere ike itinye aka na njirimara neuroprotective ya.
3. Mkpokọta Antiplatelet:Achọpụtara THP ka ọ na-egbochi nchịkọta platelet, nwere ike ibelata ihe ize ndụ nke ịmepụta mkpụkọ ọbara na ihe omume obi metụtara ya.
4. Nkwado ahụike afọ:THP egosila mmetụta mgbochi ọnya na ọ nwere ike inye aka n'ibelata secretion acid gastric, na-enye ahụ efe site na ọnya afọ na ọnọdụ ndị metụtara ya.
5. Ọrụ Antitumor nwere ike ime:THP egosila mmetụta cytotoxic na mkpụrụ ndụ tumo, na-atụ aro ọrụ nwere ike igbochi uto tumor.
6. Njirimara mgbochi riri ahụ:A mụọla THP maka ikike ọ nwere ibelata mgbaàmà nkwụsị nke metụtara opioid na ihe na-akpali akpali, na-enye nkwa na ọgwụgwọ riri ahụ na mgbochi nlọghachi azụ.
Atụmatụ ndị a na-egosipụta uru ahụike dị iche iche yana ngwa ọgwụgwọ nke Tetrahydropalmatine (THP).
Tetrahydropydalin (dl-THP) bụ nke isoquinoline alkaloids na bụ alkaloid, tumadi na genus Corydalis lucidum (Yan Hu Suo), kamakwa na osisi ndị ọzọ dị ka Stephania rotunda. Osisi ndị a nwere ojiji ọdịnala na ọgwụ ahịhịa ndị China.Corydalis bụ osisi herbaceous perennial, 10 ruo 20 cm toro ogologo, nwere tubers okirikiri. Ogologo ya dị n'elu ala dị mkpụmkpụ ma dị gịrịgịrị, nwere ọnụ ọgụgụ n'elu ala. Akwụkwọ basal na akwụkwọ cauline yiri n'ụdị ya, nwere stalks; Akwụkwọ cauline bụ nke ọzọ, nwere 2 na 3 compound epupụta. Akwụkwọ nke abụọ na-agbawakarị ezughị ezu ma na-agbawa nke ukwuu. Akwụkwọ ndị dị obere bụ oval, oval ma ọ bụ oval. Linear, ihe dị ka 2 cm n'ogologo, nwere ọnụ na-enweghị isi ma ọ bụ dị nkọ na akụkụ dị mma. Inflorescence ya nwere ụdị agbụrụ agbụrụ, nwere ọnụ ma ọ bụ akwụkwọ na-abụghị nke ya; bracts bụ lanceolate sara mbara; okooko osisi na-acha ọbara ọbara-acha odo odo ma na-eto n'ahịrị na pedicels ndị dị gịrịgịrị, nke dị ihe dịka 6 mm n'ogologo; calyx dara n'isi; na petals bụ 4 na mpụta whorls bụ 2 The akụkụ bụ ubé ibu, na pink n'ọnụ na bluish-acha odo odo center. Enwere otu akụkụ nke elu, na ọdụ ahụ na-agbatị ruo ogologo oge. Ogologo spur dị ihe dị ka ọkara nke ngụkọta ogologo. Akụkụ abụọ dị n'ime dị warara karịa akụkụ abụọ nke mpụta. Ngwunye elu bụ acha anụnụ anụnụ-acha odo odo ma gwọọ ya, na akụkụ nke ala bụ pink; Stamens bụ 6, na filaments na-ejikọta ya na ngwugwu abụọ, nke ọ bụla nwere 3 anthers; ovary dị larịị-cylindrical, ụdị ahụ dị mkpụmkpụ ma dị gịrịgịrị, na ihere bụ 2, dị ka obere urukurubụba. Mkpụrụ ya bụ capsule. A na-emepụta Corydalis na ugwu ma ọ bụ ala ahịhịa. Ebe ndị a na-emepụta ihe gụnyere Zhejiang, Hebei, Shandong, Jiangsu, na ebe ndị ọzọ.
| Nyocha | Nkọwapụta |
| Nyocha | Tetrahydropalmatine ≥98% |
| Ọdịdị | Ọkụ na-acha odo odo na ntụ ntụ ọcha |
| Ash | ≤0.5% |
| Mmiri | ≤5.0% |
| Ọgwụ nje | Ihe ọjọọ |
| Ọla dị arọ | ≤10ppm |
| Pb | ≤2.0pm |
| As | ≤2.0pm |
| Isi | Njirimara |
| Nha urughuru | 100% site na 80 mesh |
| Microbiological: | |
| Ngụkọta nje bacteria | ≤1000cfu/g |
| Fungi | ≤100cfu/g |
| Salmgosella | Ihe ọjọọ |
| Coli | Ihe ọjọọ |
Nke a bụ ụlọ ọrụ ngwa ngwaahịa nke Tetrahydropalmatine (THP):
1. ọgwụ:A na-eji THP na ụlọ ọrụ ọgwụ maka ịmepụta ọgwụ nchịkwa mgbu na ọgwụ neuroprotective.
2. Ihe oriri na-edozi ahụ:A na-eji THP na ụlọ ọrụ na-edozi ahụ maka ịmepụta ihe mgbakwunye na-elekwasị anya enyemaka mgbu na nkwado ahụike gastric.
3. Biotechnology:THP na-achọta ngwa na teknụzụ biotechnology maka nyocha n'ime ọgwụgwọ antiplatelet yana ihe mgbakwunye ọgwụgwọ ọrịa cancer nwere ike.
4. Nlekọta ahụike:Ejikọtara THP n'ime ngwaahịa nlekọta ahụike maka ijikwa ahụ riri ahụ na mgbagha mgbagha metụtara opioid na iji mkpali.
5. Ihe ịchọ mma:A na-enyocha THP na cosmeceuticals maka ahụike anụ ahụ nwere ike yana ngwa mgbochi mkpali.
Ụlọ ọrụ ndị a na-egosipụta ngwa dị iche iche nke Tetrahydropalmatine (THP) na mmepe ngwaahịa dị iche iche na ọnọdụ nyocha.
A na-arụpụta ngwaahịa anyị site na iji usoro njikwa mma siri ike ma na-agbaso ụkpụrụ dị elu nke usoro mmepụta. Anyị na-ebute nchekwa na ịdị mma nke ngwaahịa anyị ụzọ, na-ahụ na ọ na-emezu ihe ndị a chọrọ n'usoro iwu na asambodo ụlọ ọrụ. Nkwenye a maka ịdị mma bụ iji guzobe ntụkwasị obi na ntụkwasị obi na ntụkwasị obi nke ngwaahịa anyị. Usoro mmepụta n'ozuzu bụ nke a:
Nchekwa:Debe ebe dị jụụ, kpọrọ nkụ na ebe dị ọcha, Chebe mmiri na ọkụ ozugbo.
Ngwungwu nnukwu:20~25kg / agba.
Etiti oge:7 ụbọchị mgbe iwu gị.
Ndụ nchekwa:afọ 2.
Okwu:Enwere ike nweta nkọwapụta ahaziri iche.
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Site n'ikuku
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