Vinca Rosea weputara Vincristine

Ebe Latin:Catharanthus roseus (L.) G. Don
Aha ndị ọzọ:Vinca Rosea, Madagascar periwinkle, Rosy periwinkle, Vinca; Ochie nwa agbọghọ; Cape periwinkle, Rose periwinkle;
Nkọwapụta ngwaahịa:Vincristine> 98%
Oke wepụta:4:1-20:1
Ihe na-arụ ọrụ:Vincristine
Ọdịdị:White Crystalline ntụ ntụ
Eji Akụkụ osisi:Ifuru
Wepụta Ngwọta:Mmiri/Ethanol
Njirimara:Anti-ancer, na-emebi uto mkpụrụ ndụ kansa

 


Nkọwa ngwaahịa

Ozi ndị ọzọ

Mkpado ngwaahịa

Okwu Mmalite ngwaahịa

Vinca Rosea Extract Vincristine na-ezo aka na ọgwụ ọgwụ Vincristine, nke sitere na osisi periwinkle (Vinca rosea), nke a na-akpọkwa Catharanthus roseus, anya na-egbuke egbuke, Cape periwinkle, ili ili, Madagascar periwinkle, agadi odibo, pink periwinkle, rose rose. periwinkle, bụ ụdị osisi na-akụ ifuru na ezinụlọ Apocynaceae.
Vincristine bụ alkaloid sitere n'okike ma jiri ya dị ka ọgwụ chemotherapy na-agwọ ụdị ọrịa kansa dị iche iche, gụnyere leukemia, lymphoma, na etuto siri ike. Ọ na-arụ ọrụ site na imebi uto mkpụrụ ndụ kansa.

Nkọwapụta (COA)

Isi ihe na-arụ ọrụ na Chinese Aha bekee CAS Mba. Ibu molekụla Usoro ihe omimi
长春胺 Vincamine 1617-90-9 354.44 C21H26N2O3
脱水长春碱 Anhydrovinblastine 38390-45-3 792.96 C46H56N4O8
異長春花苷內酰胺 Stritosamide 23141-25-5 498.53 C26H30N2O8
四氢鸭脚木碱 Tetrahydroalstonine 6474-90-4 352.43 C21H24N2O3
酒石酸长春瑞滨 Vinorelbine Tartrate 125317-39-7 1079.12 C45H54N4O8.2(C4H6O6);C
长春瑞滨 Vinorelbine 71486-22-1 778.93 C45H54N4O8
长春新碱 Vincristine 57-22-7 824.96 C46H56N4O10
硫酸长春新碱 Vincristine sulfate 2068-78-2 923.04 C46H58N4O14S
硫酸长春质碱 Catharanthine sulfate 70674-90-7 434.51 C21H26N2O6S
酒石酸长春质碱 Catharanthine hemitartrate 4168-17-6 486.51 C21H24N2O2.C4H6O6
长春花碱 Vinblastine 865-21-4 810.99 C46H58N4O9
长春质碱 Catharanthine 2468-21-5 336.43 C21H24N2O2
文朵灵 Vindoline 2182-14-1 456.53 C25H32N2O6
硫酸长春碱 Vinblastine sulfate 143-67-9 909.05 C46H60N4O13S
β-谷甾醇 β-Sitosterol 83-46-5 414.71 C29H50O
菜油甾醇 Campesterol 474-62-4 400.68 C28H48O
齐墩果酸 Oleanolic acid 508-02-1 456.7 C30H48O3

 

Nkọwapụta ngwaahịa
Aha ngwaahịa: Vinca rosea pụtara
Aha Botanic: Catharanthus roseus (L.)
Akụkụ nke osisi Ifuru
Mba onye si: China
Ihe nyocha Nkọwapụta UZỌ anwale
Ọdịdị Ezigbo ntụ ntụ Organoleptic
Agba Brown mma ntụ ntụ Anya
Isi & uto Njirimara Organoleptic
njirimara Yiri ihe nlele RS HPTLC
Wepụta oke 4:1-20:1; Vincristine 98% nkeji
Nyocha Sieve 100% ruo 80 mesh USP39 <786>
Ọnwụ na ihicha ≤5.0% Eur.Ph.9.0 [2.5.12]
Mkpokọta ntụ ≤5.0% Eur.Ph.9.0 [2.4.16]
Ndu (Pb) ≤ 3.0 mg / kg Eur.Ph.9.0 <2.2.58>ICP-MS
Arsenic (dị ka) ≤ 1.0 mg/kg Eur.Ph.9.0 <2.2.58>ICP-MS
Cadmium (Cd) ≤ 1.0 mg/kg Eur.Ph.9.0 <2.2.58>ICP-MS
Mercury (Hg) ≤ 0.1 mg/kg -Reg.EC629/2008 Eur.Ph.9.0 <2.2.58>ICP-MS
Igwe dị arọ ≤ 10.0 mg / kg Eur.Ph.9.0 <2.4.8>
Ihe fọdụrụnụ Mee ka Eur.ph. 9.0 <5,4> na EC European Ntuziaka 2009/32 Eur.Ph.9.0 <2.4.24>
Ihe fọdụrụ na-egbu egbu Kwado ụkpụrụ (EC) No.396/2005 gụnyere mgbakwunye na mmelite na-esochi

Reg.2008/839/OA

Chromatography nke gas
Aerobic bacteria (TAMC) ≤10000 cfu/g USP39 <61>
Yist/Moulds (TAMC) ≤1000 cfu/g USP39 <61>
Escherichia coli: Adịghị na 1g USP39 <62>
Salmonella spp: Adịghị na 25g USP39 <62>
Staphylococcus aureus: Adịghị na 1g
Listeria monocytogenes Adịghị na 25g
Aflatoxins B1 ≤ 5 ppb -Reg.EC 1881/2006 USP39 <62>
Aflatoxins ∑ B1, B2, G1, G2 ≤ 10 ppb -Reg.EC 1881/2006 USP39 <62>

Njirimara ngwaahịa

Njirimara ngwaahịa nke Vinca Rosea Extract Vincristine nwere ike ịgụnye:
Ịdị ọcha dị elu:Ngwaahịa Vincristine na-enwekarị ịdị ọcha dị elu ma na-agbaso ụkpụrụ siri ike maka imepụta ọgwụ iji hụ na ịdị ọcha na nkwụsi ike nke ọgwụ ahụ.
Isi mmalite traceability:A na-ewepụtakarị Vincristine site na osisi Catharanthus roseus. Usoro mmepụta ya bụ nke a na-achọpụta ma na-agbaso nchịkọta na mmepụta nkọwa nke ọgwụ ọgwụ.
Nkwụsi ike kemịkalụ:Dịka ogige alkaloid, vincristine nwere nkwụsi ike kemịkalụ dị mma ma dabara maka mmepụta ọgwụ na nchekwa ogologo oge.
Ọrụ mgbochi tumor:Dị ka ọgwụ mgbochi tumor, vincristine nwere ọrụ nke igbochi uto na mgbasa nke mkpụrụ ndụ tumo ma dị mma maka ọgwụgwọ ọrịa cancer dị iche iche.
Nyocha ụlọ ọgwụ:Achọpụtala Vincristine n'ụlọ ọgwụ ma jiri ya mee ihe n'ọtụtụ ebe na omume ahụike, yana nkwado data mmetụta ọgwụ na ahụike pụrụ ịdabere na ya.
Njirimara ngwaahịa ndị a na-egosipụta ịdịmma, ọrụ, na uru ụlọ ọgwụ nke vincristine dị ka ọgwụ dị mkpa na-egbochi ọrịa kansa.

Uru ahụike

Vinca Rosea Extract Vincristine bụ nke ama ama maka ngwa ọgwụ ya na ọgwụgwọ ọrịa kansa na anaghị ejikọta ya na uru ahụike ozugbo maka ojiji ndị ahịa n'ozuzu. Vincristine, nke sitere na osisi Vinca rosea, bụ ọgwụ chemotherapy siri ike a na-eji agwọ ụdị ọrịa cancer dị iche iche, gụnyere leukemia, lymphoma, na etuto siri ike. Ọ na-arụ ọrụ site na itinye aka na uto nke mkpụrụ ndụ kansa.

Ọ dị mkpa iburu n'obi na Vincristine bụ ọgwụ ndenye ọgwụ na-enye n'okpuru nlekọta nke ndị ọkachamara ahụike, yana ojiji ya na-emetụta mmetụta na ihe egwu nwere ike ime. Ya mere, a naghị ere ya ma ọ bụ rie ya maka uru ahụike ya na-abụghị ntọala ụlọ ọgwụ.

Ngwa

Ngwa zuru ezu nke Vinca Rosea Extract Vincristine gụnyere:
Ọgwụgwọ Ọrịa Cancer:A na-ejikarị Vincristine na-agwọ ụdị ọrịa cancer dị iche iche, gụnyere leukemia, lymphoma, na etuto siri ike. A na-enye ya dịka akụkụ nke usoro ọgwụgwọ chemotherapy iji gbochie uto mkpụrụ ndụ kansa.
Nnyocha ọgwụ:A na-eji ihe amịpụta ahụ mee ihe na nyocha ọgwụ maka mmepe nke ọgwụgwọ ọrịa cancer ọhụrụ na ọmụmụ nke usoro ya.
Chemistry ọgwụ:Vincristine na-eje ozi dị ka ihe bara uru na ngalaba nke ọgwụ kemịkalụ, na-enye aka na mmepe nke ọgwụ ọhụrụ na ndị na-agwọ ọrịa.
Biotechnology:Enwere ike iji ihe wepụta ahụ rụọ ọrụ na ngwa biotechnological, dị ka mmepụta nke ọgwụ mgbochi ọrịa cancer na usoro nnyefe ọgwụ.
Ọnwụnwa ụlọọgwụ:Vincristine na-etinye aka na ule ụlọ ọgwụ iji chọpụta irè ya n'ịgwọ ụdị ọrịa cancer dị iche iche na iji nyochaa ngwa nwere ike na ọnọdụ ahụike ndị ọzọ.
Nhazi ọgwụ:A na-eji mpempe akwụkwọ eme ihe n'ichepụta ngwaahịa ọgwụ, gụnyere ngwọta injectable na ụdị ọgwụgwọ ndị ọzọ maka ọgwụgwọ ọrịa cancer.
Ngwa ndị a gosipụtara ojiji dị iche iche nke Vinca Rosea Extract Vincristine na ọgwụgwọ ọrịa kansa, nyocha ọgwụ na mmepe ọgwụ.

Mmetụta nwere ike ime

Vincristine bụ ọgwụ chemotherapy siri ike, yana ojiji ya nwere ike jikọta ya na mmetụta dị iche iche nwere ike ime. Ụfọdụ n'ime mmetụta ndị nwere ike ime nke Vincristine ntụ ntụ nwere ike ịgụnye:
Neurotoxicity:Vincristine nwere ike imebi usoro ụjọ ahụ nke dị n'akụkụ, na-eduga na mgbaàmà dịka nhụjuanya, nkwụsịtụ, na adịghị ike na njedebe.
Mmetụta Gastrointestinal:Mmetụta eriri afọ na-emekarị nwere ike ịgụnye ọgbụgbọ, ọgbụgbọ, afọ ntachi, na mgbu afọ.
Mbelata ụmị ọkpụkpụ:Vincristine nwere ike igbochi ụmị ọkpụkpụ, na-eduga n'ịbelata mmepụta nke mkpụrụ ndụ ọbara, nke nwere ike ịkpata anaemia, ịba ụba nke ọrịa, na ọbara ọgbụgba.
Ntutu isi:Ụfọdụ ndị mmadụ nwere ike ịnwe ntutu isi ma ọ bụ ịcha ntutu n'ihi ọgwụgwọ Vincristine.
Ụka mgbu:Vincristine nwere ike ịkpata ụdị mgbu a na-akpọ "vincristine-induced neuropathy-acute-onset," nke a na-eji mgbu agba na ihe isi ike ilo.
Mmetụta ndị ọzọ nwere ike ime:Mmetụta ndị ọzọ nwere ike ịgụnye adịghị ike akwara, mgbanwe nke ọbara mgbali elu, na mmeghachi ahụ nfụkasị ahụ.
Ọ dị mkpa ịmara na ndepụta a dị n'elu adịghị agwụ agwụ, ndị ọkachamara ahụike kwesịrị ileba anya nke ọma na ndị mmadụ na-anata Vincristine maka mmetụta ọ bụla nwere ike ime. Mmetụta ndị a kapịrị ọnụ na ịdị njọ ha nwere ike ịdịgasị iche site na mmadụ gaa na onye. Ndị ọrịa kwesịrị iso ndị na-ahụ maka ahụike ha kwurịta mmetụta ndị nwere ike ime na nchegbu tupu ha amalite ọgwụgwọ Vincristine.


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    Nkọwapụta mmepụta (Chatịnụ usoro)

    1. Isi mmalite na owuwe ihe ubi
    2. Mwepụta
    3. Ntụkwasị obi na ịdị ọcha
    4. ihicha
    5. Standardization
    6. njikwa mma
    7. Nkwakọ ngwaahịa 8. Nkesa

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