Ka akpụkpọ ahụ na-akawanye nká, a na-ebelata ọrụ physiologic. A na-ebute mgbanwe ndị a site na ma ihe dị n'ime (chronologic) na extrinsic (na-ebutekarị UV). Botanicals na-enye uru ndị nwere ike ịlụso ụfọdụ n'ime ihe ịrịba ama nke ịka nká ọgụ. N'ebe a, anyị na-enyocha ahọpụtara botanicals na akaebe sayensị n'azụ nzọrọ ha mgbochi ịka nká. Botanicals nwere ike inye mgbochi mkpali, antioxidant, moisturizing, UV-echebe, na ndị ọzọ mmetụta. Edepụtara ọtụtụ ihe ọkụkụ dị ka ihe eji eme ihe ịchọ mma na ihe ịchọ mma na-ewu ewu, mana ọ bụ naanị ole na ole ahọpụtara ka a tụlere ebe a. A họọrọ ndị a dabere na nnweta data sayensị, mmasị onwe onye nke ndị na-ede akwụkwọ, na echiche "ewu ewu" nke ngwaahịa ịchọ mma na ihe ịchọ mma ugbu a. Ihe omumu ihe omumu a nyochara ebe a gunyere mmanụ argan, mmanụ aki oyibo, crocin, feverfew, tii green, marigold, pọmigranet, na soy.
isiokwu: botanical; mgbochi ịka nká; mmanụ argan; mmanụ aki oyibo; crocin; anụ ọkụkọ; tii tii; marigolds; mkpụrụ pọmigranet; soy
3.1. Mmanụ argan
3.1.1. Akụkọ ihe mere eme, ojiji na nkwupụta
Argan mmanụ bụ endemic na Morocco na-emepụta site na mkpụrụ nke Argania sponosa L. O nwere ọtụtụ omenala ojiji dị ka isi nri, na-agwọ ọrịa akpụkpọ, na akpụkpọ na ntutu nlekọta.
3.1.2. Nhazi na usoro nke ime ihe
Mmanụ Argan mejupụtara 80% abụba monounsaturated yana 20% fatty acids ma nwee polyphenols, tocopherols, sterols, squalene na mmanya triterpene.
3.1.3. Ihe akaebe sayensị
A na-ejikarị mmanụ Argan eme ihe na Morocco iji belata pigmenti ihu, mana aghọtachaghị ihe ndabere sayensị maka nkwupụta a. Na nyocha nke òké, mmanụ argan gbochiri tyrosinase na dopachrome tautomerase okwu na B16 murine melanoma sel, na-ebute mbelata na-adabere na dose na ọdịnaya melanin. Nke a na-egosi na mmanụ argan nwere ike ịbụ ihe na-egbochi melanin biosynthesis, mana a na-enyocha ule nchịkwa (RTC) n'ime ihe ndị mmadụ na-eme iji nyochaa echiche a.
Otu obere RTC nke ụmụ nwanyị 60 post-menopausal na-atụ aro na oriri kwa ụbọchị na / ma ọ bụ ngwa ngwa nke mmanụ argan na-ebelata mmiri transepidermal (TEWL), na-eme ka akpụkpọ ahụ dịkwuo mma, dabere na mmụba na R2 (oke elasticity nke akpụkpọ ahụ), R5. (net elasticity nke akpụkpọ), na R7 (biological elasticity) paramita na mbelata resonance na-agba ọsọ oge (RRT) (atụ inversely metụtara akpụkpọ elasticity). A na-ahapụrụ otu ndị ahụ ka ha rie mmanụ oliv ma ọ bụ mmanụ argan. Otu abụọ ahụ tinye mmanụ argan na nkwojiaka aka ekpe naanị. Ewere ihe nlegharị anya site n'aka aka nri na aka ekpe. A na-ahụ ọganihu na ngbanwe n'òtù abụọ ahụ na nkwojiaka ebe a na-etinye mmanụ argan n'elu, ma na nkwojiaka ebe a na-etinyeghị mmanụ argan naanị otu ndị na-eri mmanụ argan nwere mmụba dị ukwuu na elasticity [31]. Nke a bụ n'ihi ụbara ọdịnaya antioxidant dị na mmanụ argan ma e jiri ya tụnyere mmanụ oliv. A na-eche na nke a nwere ike ịbụ n'ihi vitamin E na ọdịnaya ferulic acid, nke a maara na antioxidants.
3.2. Mmanụ aki oyibo
3.2.1. Akụkọ ihe mere eme, ojiji na nkwupụta
A na-enweta mmanụ aki oyibo site na mkpụrụ osisi a mịrị amị nke Cocos nucifera ma nwee ọtụtụ ojiji, ma akụkọ ihe mere eme na nke oge a. Ejiri ya dị ka ihe na-esi ísì ụtọ, akpụkpọ anụ, na ntutu isi, yana n'ọtụtụ ngwaahịa ịchọ mma. Ọ bụ ezie na mmanụ aki oyibo nwere ọtụtụ usoro, gụnyere aki oyibo, hydrogenated aki oyibo, na hydrogenated mmanụ aki oyibo, anyị ga-atụle nnyocha na-ekwu na predominately na-amaghị nwoke aki oyibo mmanụ (VCO), nke a kwadebere na-enweghị okpomọkụ.
A na-eji mmanụ aki oyibo mee ihe maka ịmịnye akpụkpọ anụ nwa ọhụrụ ma nwee ike ịba uru na ọgwụgwọ nke atopic dermatitis maka ma ihe ndị na-eme ka mmiri na-egbuke egbuke na mmetụta ya nwere na Staphylococcus aureus na ụmụ nje ndị ọzọ na-ahụ maka anụ ahụ na ndị ọrịa atopic. E gosiputara mmanụ aki oyibo na-ebelata S. aureus colonization na akpụkpọ anụ ndị okenye nwere atopic dermatitis na RTC okpukpu abụọ.
3.2.2. Nhazi na usoro nke ime ihe
Mmanụ aki oyibo bụ 90-95% juputara triglycerides (lauric acid, myristic acid, caprylic acid, capric acid, na palmitic acid). Nke a dị iche na ọtụtụ mmanụ nri/mkpụrụ osisi, bụ nke na-abụkarị abụba na-ejughi afọ. triglycerides juru eju etinyere n'elu na-arụ ọrụ iji mee ka akpụkpọ ahụ dị ka ihe na-ekpo ọkụ site n'iwetu akụkụ nke corneocytes akọrọ akọrọ ma na-ejuputa oghere dị n'etiti ha.
3.2.3. Ihe akaebe sayensị
Mmanụ aki oyibo nwere ike moisturize akọrọ ịka nká akpụkpọ. Pasent iri isii na abụọ nke fatty acids na VCO nwere ogologo ogologo na 92% juputara, nke na-enye ohere maka ịkwakọ ngwaahịa siri ike nke na-ebute mmetụta dị egwu karịa mmanụ oliv. A na-agbaji triglycerides dị na mmanụ aki oyibo site na lipases na ahịhịa anụ ahụ nkịtị ruo glycerin na acid fatty. Glycerin bụ ihe na-eme ka mmiri dị ike, nke na-adọta mmiri na corneal oyi akwa nke epidermis site na gburugburu ebe dị n'èzí na akpụkpọ anụ dị omimi. Acids fatty na VCO nwere obere linoleic acid, nke dị mkpa ebe ọ bụ na linoleic acid nwere ike ịkpasu akpụkpọ ahụ iwe. Mmanụ aki oyibo dị elu karịa mmanụ ịnweta na ibelata TEWL na ndị ọrịa nwere atopic dermatitis ma dị irè ma dị mma dị ka mmanụ ịnweta mmanụ n'ịgwọ xerosis.
Lauric acid, onye na-ebute monolaurin na akụkụ dị mkpa nke VCO, nwere ike ịnwe ihe ndị na-egbochi mkpali, nwee ike imezi mgbasawanye cell nke na-alụso ọrịa ọgụ ma bụrụ maka ụfọdụ mmetụta antimicrobial nke VCO. VCO nwere ọkwa dị elu nke ferulic acid na p-coumaric acid (ma phenolic acid), na nnukwu ọkwa nke acid phenolic ndị a na-ejikọta ya na ikike antioxidant na-abawanye. Phenolic acid dị irè megide mmebi nke UV kpatara. Agbanyeghị, n'agbanyeghị na-ekwu na mmanụ aki oyibo nwere ike ịrụ ọrụ dị ka ihe mkpuchi anwụ, ihe ọmụmụ vitro na-egosi na ọ na-enye ikike igbochi UV-na-enweghị.
Na mgbakwunye na mmetụta moisturize na antioxidant, ụdị anụmanụ na-atụ aro na VCO nwere ike ibelata oge ọgwụgwọ ọnya. Enwere ụbara ọkwa nke pepsin-soluble collagen (collagen cross-linking dị elu) na ọnyá ndị VCO na-agwọ ma e jiri ya tụnyere njikwa. Histopathology gosipụtara mmụba fibroblast na-abawanye na neovascularization na ọnya ndị a. Ọmụmụ ihe ọzọ dị mkpa iji hụ ma ngwa ngwa VCO nwere ike ịbawanye ọkwa collagen na akpụkpọ ahụ mmadụ merela agadi.
3.3. Crocin
3.3.1. Akụkọ ihe mere eme, ojiji, nkwupụta
Crocin bụ ihe na-arụsi ọrụ ike nke saffron, nke sitere na mkparị a mịrị amị nke Crocus sativus L. Saffron na-akọ n'ọtụtụ mba gụnyere Iran, India, na Gris, ma jiri ya na ọgwụ ọdịnala iji belata ọrịa dịgasị iche iche gụnyere ịda mbà n'obi, mbufụt. , ọrịa imeju, na ọtụtụ ndị ọzọ.
3.3.2. Nhazi na usoro nke ime ihe
Crocin na-ahụ maka agba saffron. A na-ahụkwa Crocin na mkpụrụ osisi Gardenia jasminoides Ellis. A na-ekewa ya dị ka carotenoid glycoside.
3.3.3. Ihe akaebe sayensị
Crocin nwere mmetụta antioxidant, na-echebe squalene megide peroxidation nke UV na-ebute, ma na-egbochi ntọhapụ nke ndị mgbasa ozi mkpali. Egosiputa mmetụta antioxidant na nyocha in vitro nke gosipụtara ọrụ antioxidant dị elu ma e jiri ya tụnyere Vitamin C. Ọzọkwa, crocin na-egbochi UVA-induced cell membrane peroxidation ma na-egbochi okwu nke ọtụtụ ndị mgbasa ozi pro-inflammatory gụnyere IL-8, PGE-2, IL. -6, TNF-a, IL-1a, na LTB4. Ọ na-ebelata nkwupụta nke ọtụtụ mkpụrụ ndụ ihe nketa NF-κB. N'ime ọmụmụ ihe site na iji fibroblasts mmadụ, crocin belatara UV-induced ROS, kwalitere ngosipụta nke protein matrix extracellular Col-1, ma belata ọnụ ọgụgụ sel ndị nwere phenotypes senescent mgbe UV radieshon gasịrị. Ọ na-ebelata mmepụta ROS ma gbochie apoptosis. E gosipụtara Crocin ka ọ kwụsịlata ụzọ mgbaàmà ERK/MAPK/NF-κB/STAT na mkpụrụ ndụ HaCaT na vitro. Ọ bụ ezie na crocin nwere ikike dị ka ihe na-egbochi ịka nká cosmeceutical, ogige ahụ bụ labile. enyochala ojiji nke nanostructured lipid dispersions maka n'elu nchịkwa na-ekwe nkwa nsonaazụ. Iji chọpụta mmetụta nke crocin na vivo, a chọrọ ụdị anụmanụ ndị ọzọ na nnwale ụlọ ọgwụ na-enweghị usoro.
3.4. Feverfew
3.4.1. Akụkọ ihe mere eme, ojiji, nkwupụta
Feverfew, Tanacetum parthenium, bụ ahịhịa na-adịru afọ nke ejirila ọtụtụ ebumnuche na ọgwụ ndị mmadụ.
3.4.2. Nhazi na usoro nke ime ihe
Feverfew nwere parthenolide, lactone sesquiterpene, nke nwere ike ịbụ maka ụfọdụ mmetụta mgbochi mkpali ya, site na mgbochi nke NF-κB. Mgbochi a nke NF-κB yiri ka ọ nọọrọ onwe ya na mmetụta antioxidant nke parthenolide. Parthenolide egosipụtakwala mmetụta anticancer megide ọrịa kansa anụ ahụ nke UVB kpatara yana megide mkpụrụ ndụ melanoma na vitro. N'ụzọ dị mwute, parthenolide nwekwara ike ịkpata mmeghachi ahụ nfụkasị ahụ, ọnya ọnụ, na kọntaktị dermatitis nfụkasị ahụ. N'ihi nchegbu ndị a, a na-ewepụ ya ugbu a tupu etinyekwa feverfew na ngwaahịa ịchọ mma.
3.4.3. Ihe akaebe sayensị
N'ihi nsogbu ndị nwere ike na iji parthenolide eme ihe, ụfọdụ ngwaahịa ịchọ mma dị ugbu a nwere feverfew na-eji parthenolide-depleted feverfew (PD-feverfew), nke na-ekwu na ọ nweghị ikike nghọta. PD-feverfew nwere ike ịkwalite ọrụ mmezi DNA na-arụ ọrụ na akpụkpọ ahụ, nwere ike ibelata mmebi DNA nke UV kpatara. N'ime ọmụmụ in vitro, PD-feverfew kpalitere nguzobe hydrogen peroxide nke UV na-ebute ma belata ntọhapụ cytokine pro-inflammatory. Ọ gosipụtara mmetụta antioxidant siri ike karịa onye comparator, Vitamin C, yana mbelata erythema nke UV na-akpata na isiokwu 12 RTC.
3.5. Green tii
3.5.1. Akụkọ ihe mere eme, ojiji, nkwupụta
A na-eri tii Green maka uru ahụike ya na China ruo ọtụtụ narị afọ. N'ihi mmetụta antioxidant ya siri ike, enwere mmasị na mmepe nke usoro ihe kwụsiri ike, nke nwere ike ịdị ndụ.
3.5.2. Nhazi na usoro nke ime ihe
Green tii, sitere na Camellia sinensis, nwere otutu ogige bioactive nwere mmetụta mgbochi ịka nká, gụnyere caffeine, vitamin, na polyphenols. Isi polyphenols na tii green bụ catechins, akpan akpan gallocatechin, epigallocatechin (ECG), na epigallocatechin-3-gallate (EGCG). Epigallocatechin-3-gallate nwere antioxidant, photoprotective, immunomodulatory, anti-angiogenic, na mgbochi mkpali Njirimara. Green tii nwekwara nnukwu ego nke flavonol glycoside kaempferol, nke na-amịnye nke ọma na akpụkpọ ahụ mgbe ọ gbasịrị ngwa ngwa.
3.5.3. Ihe akaebe sayensị
Green tii wepụ na-ebelata intracellular ROS mmepụta na vitro ma belata ROS-induced necrosis. Epigallocatechin-3-gallate (a na-acha akwụkwọ ndụ tii polyphenol) na-egbochi mwepụta nke hydrogen peroxide nke UV, na-egbochi phosphorylation nke MAPK, ma na-ebelata mbufụt site na ntinye nke NF-κB. N'iji ex vivo akpụkpọ sitere na nwanyị dị afọ 31 dị mma, akpụkpọ anụ nke ejiri ọcha ma ọ bụ tii tii tii mee ihe gosipụtara njigide nke mkpụrụ ndụ Langerhans (sel ndị na-eweta antigen na-ahụ maka ntinye nke mgbochi na akpụkpọ ahụ) mgbe ikpughe ọkụ UV.
N'ụdị òké, ngwa n'elu nke akwụkwọ ndụ akwụkwọ ndụ tii wepụ tupu ikpughe UV butere mbelata erythema, mbelata infiltration nke leukocytes akpụkpọ anụ, na mbelata ọrụ myeloperoxidase. Ọ nwekwara ike igbochi 5-a-reductase.
Ọtụtụ ọmụmụ metụtara isiokwu ụmụ mmadụ enyochala uru dị na ngwa tii akwụkwọ ndụ akwụkwọ ndụ. Ngwa dị n'elu nke emulsion tii akwụkwọ ndụ akwụkwọ ndụ gbochiri 5-a-reductase wee bute mbelata nha microcomedone na ihe otutu microcomedonal. N'ime obere ọmụmụ ihe nkewa nke mmadụ n'izu isii, ude nwere EGCG belatara hypoxia-inducible factor 1 α (HIF-1a) na vaskụla endothelial growth factor (VEGF), na-egosipụta ikike igbochi telangiectasias. N'ime nnyocha kpuru ìsì okpukpu abụọ, ma ọ bụ tii tii, tii ọcha, ma ọ bụ ụgbọ ala ka etinyere naanị n'azụ nke ndị ọrụ afọ ofufo 10 nwere ahụike. A na-ejizi 2 × minimal erythema dose (MED) jiri UVR simulated nke anwụ na-agbapụta akpụkpọ ahụ. Nnyocha anụ ahụ sitere na saịtị ndị a gosipụtara na itinye akwụkwọ ndụ akwụkwọ ndụ ma ọ bụ tii ọcha nwere ike ibelata mbelata nke mkpụrụ ndụ Langerhans nke ukwuu, dabere na CD1a positivity. Enwekwara mgbochi akụkụ nke mmebi DNA oxidative nke UV kpatara, dị ka egosipụtara site na mbelata ọkwa 8-OHdG. N'ọmụmụ ihe dị iche, ndị ọrụ afọ ofufo 90 bụ ndị na-enweghị usoro n'ime otu atọ: Enweghị ọgwụgwọ, tii green tii, ma ọ bụ tii ọcha. E kewakwara otu ọ bụla n'ọkwa dị iche iche nke radieshon UV. Achọpụtara ihe nchekwa anwụ na vivo dị ihe dịka SPF 1.
3.6. Marigold
3.6.1. Akụkọ ihe mere eme, ojiji, nkwupụta
Marigold, Calendula officinalis, bụ osisi ifuru na-esi ísì ụtọ nke nwere ike ịgwọ ọrịa. A na-eji ya na nkà mmụta ọgwụ ndị mmadụ na Europe na United States dị ka ọgwụ n'elu maka ọkụ ọkụ, ọnya, mbepụ, na rashes. Marigold egosila mmetụta anticancer na ụdị murine nke ọrịa kansa anụ ahụ na-abụghị melanoma.
3.6.2. Nhazi na usoro nke ime ihe
Ihe ndị bụ isi kemịkalụ nke marigolds bụ steroid, terpenoids, free na esterified triterpene alcohols, phenolic acid, flavonoids, na ogige ndị ọzọ. Ọ bụ ezie na otu nnyocha gosipụtara na ngwa ngwa nke marigold wepụ nwere ike ibelata ịdị njọ na mgbu nke dermatitis radiation na ndị ọrịa na-anata radieshon maka ọrịa ara ara, ule ndị ọzọ na-agwọ ọrịa egosila na ọ dịghị elu ma e jiri ya tụnyere itinye ude mmiri naanị.
3.6.3. Ihe akaebe sayensị
Marigold nwere ikike antioxidant egosipụtara na mmetụta cytotoxic na mkpụrụ ndụ kansa mmadụ na ụdị mkpụrụ ndụ akpụkpọ anụ in vitro. N'ime ọmụmụ ihe dị iche iche na vitro, a na-enyocha ude nwere mmanụ calendula site na UV spectrophotometric ma chọpụta na ọ nwere ihe mgbagwoju anya na nso nke 290-320 nm; Ewere nke a pụtara na ntinye nke ude a na-enye nchebe anyanwụ dị mma. Ọ dị mkpa iburu n'obi, na nke a abụghị ule in vivo nke gbakọọ opekempe erythema dose n'ime ndị ọrụ afọ ofufo mmadụ ma amabeghị ka nke a ga-esi sụgharịa na ule ụlọ ọgwụ.
N'ime ụdị in vivo murine, wepụ marigold gosipụtara mmetụta antioxidant siri ike mgbe mkpughe UV gasịrị. N'ime ọmụmụ dị iche, metụtara oke albino, ngwa ngwa nke calendula mmanụ dị mkpa na-ebelata malondialdehyde (ihe nrịbama nke nrụgide oxidative) ebe ọ na-abawanye ọkwa nke catalase, glutathione, superoxide dismutase, na ascorbic acid na akpụkpọ ahụ.
N'ime izu asatọ nke otu kpuru ìsì na mmadụ iri abụọ na otu, itinye ude calendula na cheeks na-eme ka akpụkpọ ahụ dịkwuo ike ma enweghị mmetụta ọ bụla dị ịrịba ama na ngbanwe akpụkpọ ahụ.
Mmachi nwere ike iji marigold na ihe ịchọ mma bụ na marigold bụ ihe ama ama na-akpata nfụkasị kọntaktị dermatitis, dị ka ọtụtụ ndị ọzọ so na ezinụlọ Compositae.
3.7. pọmigranet
3.7.1. Akụkọ ihe mere eme, ojiji, nkwupụta
Mkpụrụ pọmigranet, Punica granatum, nwere ikike antioxidant siri ike ma ejiri ya mee ihe n'ọtụtụ ngwaahịa dị ka antioxidant dị n'elu. Ọdịnaya antioxidant dị elu na-eme ka ọ bụrụ ihe nwere ike ime ka ọ bụrụ ihe na-adọrọ mmasị na nhazi ihe ịchọ mma.
3.7.2. Nhazi na usoro nke ime ihe
Ihe mejupụtara mkpụrụ pọmigranet na-arụ ọrụ nke ọma bụ tannins, anthocyanins, ascorbic acid, niacin, potassium, na piperidine alkaloids. Enwere ike iwepụta ihe ndị a na-arụ ọrụ ndụ site na ihe ọṅụṅụ, mkpụrụ osisi, bee, ogbugbo, mgbọrọgwụ, ma ọ bụ azuokokoosisi nke pọmigranet. A na-eche na ụfọdụ n'ime ihe ndị a nwere antitumor, mgbochi mkpali, mgbochi microbial, antioxidant, na mmetụta fotoprotective. Ọzọkwa, mkpụrụ pọmigranet bụ isi iyi nke polyphenols. Ellegic acid, bụ akụkụ nke mpụta pọmigranet, nwere ike ibelata pigmenti akpụkpọ ahụ. N'ihi ịbụ ihe na-ekwe nkwa mgbochi ịka nká, ọtụtụ ọmụmụ enyochala ụzọ iji mee ka ntinye anụ ahụ dị n'ime ogige a maka iji ihe eji eme ihe.
3.7.3. Ihe akaebe sayensị
Mkpokọta mkpụrụ pọmigranet na-echebe mmadụ fibroblasts, in vitro, site na ọnwụ cell nke UV kpatara; nwere ike ịbụ n'ihi mbelata nke NF-κB, mbelata nke proapoptotic caspace-3, na nrụzi DNA na-abawanye. Ọ na-egosiputa mmetụta mgbochi-akpụ akpụ na-akwalite mmetụta na vitro ma na-egbochi mgbanwe nke UVB nke NF-κB na ụzọ MAPK. Ngwa nke mkpụrụ pọmigranet na-amịpụta mkpụrụ pọmigranet na-agbada COX-2 n'ime akpụkpọ anụ porcine ewepụtara ọhụrụ, na-ebute mmetụta mgbochi mkpali dị ukwuu. Ọ bụ ezie na a na-echekarị ellegic acid dị ka akụkụ kachasị arụ ọrụ nke mpụta pọmigranet, ihe nlereanya murine gosipụtara ọrụ mgbochi mkpali dị elu na mpụta mkpụrụ pọmigranet a na-ahazi ma e jiri ya tụnyere ellegic acid naanị. Ngwa n'elu nke microemulsion nke mkpụrụ pọmigranet na-eji polysorbate surfactant (Tween 80®) n'ime izu iri na abụọ na-atụnyere ihu ihu na isiokwu 11, gosipụtara mbelata melanin (n'ihi mgbochi tyrosinase) ma belata erythema ma e jiri ya tụnyere njikwa ụgbọ ala.
3.8. Soy
3.8.1. Akụkọ ihe mere eme, ojiji, nkwupụta
Soybean bụ nri nwere protein dị elu nwere ihe ndị na-eme ndụ ndụ nwere ike inwe mmetụta mgbochi ịka nká. Karịsịa, soybean dị elu na isoflavones, nke nwere ike inwe mmetụta anticarcinogenic na mmetụta estrogen-dị ka n'ihi usoro diphenolic. Mmetụta ndị a yiri estrogen nwere ike ịlụso ụfọdụ mmetụta nke menopause na ịka nká akpụkpọ ahụ ọgụ.
3.8.2. Nhazi na usoro nke ime ihe
Soy, sitere na Glycine maxi, nwere protein dị elu ma nwee isoflavones, gụnyere glycitein, equol, daidzein, na genistein. Ndị a isoflavones, nke a na-akpọkwa phytoestrogens, nwere ike inwe mmetụta estrogenic na ụmụ mmadụ.
3.8.3. Ihe akaebe sayensị
Soybean nwere otutu isoflavones nwere uru mgbochi ịka nká. N'ime mmetụta ndị ọzọ dị ndụ, glycitein na-egosipụta mmetụta antioxidant. Fibroblasts nke Dermal na-eji glycitein gosipụtara mmụba nke cell na mbugharị, mmụba nke ụdị collagen I na III, ma belata MMP-1. N'ime ọmụmụ ihe dị iche, a na-ejikọta soy wepụ na heematococcus wepụ (mmiri mmiri na-adịkwa elu na antioxidants), nke mebiri MMP-1 mRNA na okwu protein. Daidzein, soy isoflavone, egosipụtala mmetụta mgbochi nhịahụ, na-amụba akpụkpọ ahụ, na mmetụta na-eme ka akpụkpọ ahụ dị ọcha. Diadzein nwere ike ịrụ ọrụ site n'ịgbalite estrogen-receptor-β n'ime akpụkpọ ahụ, na-ebute nkwupụta nkwalite nke antioxidants endogenous na mbelata okwu nke ihe odide ederede na-eduga na keratinocyte proliferation na mbugharị. Isoflavonoid equol nke soy enwetara mụbara collagen na elastin wee belata MMP na omenala cell.
Mgbakwunye na vivo murine ọmụmụ gosipụtara mbelata ọnwụ mkpụrụ ndụ UVB na mbelata ọkpụrụkpụ epidermal n'ime mkpụrụ ndụ mgbe etinyere n'elu nke mpụta isoflavone. N'ime nyocha nke pilot nke ụmụ nwanyị 30 postmenopausal, nchịkwa ọnụ nke isoflavone wepụ maka ọnwa isii mere ka ọkpụkpụ epidermal dịkwuo elu na ụbara dermal collagen dị ka a na-atụle site na biopsies akpụkpọ ahụ na ebe nchekwa anyanwụ. N'ime ọmụmụ ihe dị iche, isoflavones soy dị ọcha gbochiri ọnwụ keratinocyte nke UV kpatara wee belata TEWL, ọkpụrụkpụ epidermal, na erythema na akpụkpọ anụ òké na-ekpughere UV.
RCT na-atụ anya okpukpu abụọ nke kpuru ìsì nke ụmụ nwanyị 30 dị afọ 45-55 tụnyere ngwa ngwa nke estrogen na genistein (soy isoflavone) na akpụkpọ ahụ maka izu 24. Ọ bụ ezie na otu ndị na-etinye estrogen na akpụkpọ ahụ nwere nsonaazụ dị elu, otu abụọ ahụ gosipụtara mmụba nke ụdị I na III ihu collagen dabere na biopsies akpụkpọ anụ nke preauricular akpụkpọ. Soy oligopeptides nwere ike ibelata ihe nrịbama erythema na akpụkpọ anụ UVB ekpughere ya (ogwe aka) ma belata mkpụrụ ndụ anwụ na-acha ọkụ na cyclobutene pyrimidine dimers na mkpụrụ ndụ apị nke UVB ex vivo. Nnwale ụlọ ọgwụ izu iri na abụọ ejiri kpuru okpukpu abụọ nke agbadoro nke metụtara ụmụ nwanyị 65 nwere foto ihu na-agafeghị oke gosipụtara mmụba n'ụdị nchacha agba agba, enweghị isi, enweghị isi, ahịrị dị mma, ụdị akpụkpọ ahụ na ụda akpụkpọ ahụ ma e jiri ya tụnyere ụgbọ ahụ. Ọnụ, ihe ndị a nwere ike inye mmetụta mgbochi ịka nká, mana a ga-achọ nnwale ụlọ ọgwụ siri ike karịa iji gosipụta uru ya nke ọma.
4. Mkparịta ụka
Ngwaahịa botanical, gụnyere ndị a tụlere ebe a, nwere mmetụta mgbochi ịka nká. Usoro nke mgbochi ịka nká botanicals gụnyere ikike radical free nke antioxidants etinyere n'elu, nchebe anyanwụ na-abawanye, mmụba akpụkpọ anụ, yana ọtụtụ mmetụta na-eduga n'ịmepụta collagen ma ọ bụ ibelata ndakpọ collagen. Ụfọdụ n'ime mmetụta ndị a dị ntakịrị ma e jiri ya tụnyere ọgwụ ndị na-emepụta ọgwụ, ma nke a anaghị ebelata uru ha nwere ike ime mgbe ejiri ya na usoro ndị ọzọ dị ka ịzere anyanwụ, iji sunscreens, moisturization kwa ụbọchị na ọgwụgwọ ọkachamara ahụike kwesịrị ekwesị maka ọnọdụ akpụkpọ anụ dị ugbu a.
Na mgbakwunye, botanicals na-enye ihe ndị ọzọ na-arụ ọrụ ndu maka ndị ọrịa na-ahọrọ iji naanị ihe “eke” na akpụkpọ ahụ ha. Ọ bụ ezie na a na-ahụ ihe ndị a n'okike, ọ dị mkpa imesi ndị ọrịa ike na nke a apụtaghị na ihe ndị a nwere mmetụta ọjọọ efu, n'eziokwu, ọtụtụ ngwaahịa botanical maara na ọ bụ ihe nwere ike ịkpata dermatitis nfụkasị ahụ.
Dị ka ngwaahịa ịchọ mma anaghị achọ otu ọkwa akaebe iji gosipụta ịdị irè, ọ na-esikarị ike ikpebi ma nkwupụta nke mmetụta mgbochi ịka nká bụ eziokwu. Ọtụtụ n'ime ọgwụ ndị e depụtara ebe a, agbanyeghị, nwere mmetụta mgbochi ịka nká, mana ọ dị mkpa nnwale ụlọ ọgwụ siri ike karị. Ọ bụ ezie na ọ siri ike ịkọ otú ndị ọrụ botanical ndị a ga-esi baara ndị ọrịa na ndị na-azụ ahịa uru n'ọdịnihu, ọ ga-abụ na ọtụtụ n'ime ihe ndị a na-emepụta ihe na-eme ka ha dị ka ihe oriri ga-anọgide na-ewebata dị ka ngwaahịa nlekọta anụ ahụ ma ọ bụrụ na ha. nọgide na-enwe oke nchekwa buru ibu, nnabata ndị ahịa dị elu, na oke ego, ha ga-anọgide na-abụ akụkụ nke usoro nlekọta anụ ahụ mgbe niile, na-enye obere uru maka ahụike akpụkpọ ahụ. Maka ọnụ ọgụgụ dị nta nke ndị ọrụ botanical ndị a, agbanyeghị, enwere ike nweta mmetụta dị ukwuu nye ọha mmadụ site n'ịkwalite ihe akaebe nke omume ndụ ha, site na nyocha biomarker ọkọlọtọ dị elu ma emesịa idobe ebumnuche kachasị mma na nnwale ụlọ ọgwụ.
Oge nzipu: Mee-11-2023
